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Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. Submit your work to JBC. Search for related content. Articles by Germain, L.

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In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. Responses Submit a Letter to the Editor.

Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to 80000 formation of the stratum corneum. Classifications Mechanisms of Signal Transduction. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification.

In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.

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View this article with LENS. This Article First Published on January 28, doi: Submit your work to JBC.

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You’ll be in good company. Journal of Lipid Research. Google Scholar Articles by Robitaille, H. Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not.

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Although it is expected that the last phases of this process must be tightly regulated dkl it results in cell death, the signaling pathways involved in this induction remain ill defined.

Articles by Germain, L. In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.

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Related Content Load related web page information. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human keratinocytes. Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar 88000 in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions.

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